Posted: November 24th, 2022

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1. In a study examining smoking and lung cancer, a random sample of men between the ages of 55 and 60 was obtained. The smoking and disease status of each sampled subject was ascertained. For each subject, a ’1’ is assigned if the subject had lung cancer (case) and a ’0’ if not. Similarly, a ’1’ indicates that a subject is a smoker and a ’0’ indicates a nonsmoker. The data are found in the Excel file ‘LungCancer’. • Read the data into R, and use table() function to produce a contingency table summarizing these data. • Assuming that there is no association between smoking and lung cancer, compute a table of ‘expected’ counts. • By hand, compute the observed value of the test statistic for testing association between lung cancer and smoking. • Assuming there is no association, what is the distribution of the test statistic? • Using R, compute the p-value for a test of association, and give a detailed conclusion based on the p-value and a comparison of the tables observed and expected counts. 2. The following data are from a study examining the incidence of tuberculosis in relation to blood groups in a sample of Eskimos. It is of interest to determine if there is any association between the disease and blood group within the ABO system. Severity O A AB B Moderate-advanced 7 7 7 13 Minimal 27 34 12 18 Not Present 55 52 11 24 • Assuming that there is no association between disease and blood group, compute a table of ‘expected’ counts. • By hand, compute the observed value of the test statistic for testing association between disease and blood group. • Assuming there is no association, what is the distribution of the test statistic? • Using R, compute the p-value for a test of association, and give a detailed conclusion based on the p-value and a comparison of the tables observed and expected counts.

4. The file ‘growth’ gives data on the height of a white spruce tree measured annually for 50 years. Letting Yt denote the height of the tree at year t > 0, we consider describing the growth of the tree over time with a non-linear model Yt = f(t) + ²t , ²t iid∼ N(0, σ2 ). Three growth curves are considered for f(t) (a) Logistic: f(t) = a/(1 + b ∗ exp{−ct}) (b) Gompertz: f(t) = a exp{−b exp{−ct}} (c) Von Bertalanffy: f(t) = a − a exp{−b(t + c)} • Fit all three models using the non-linear least squares function nls() in R. Explain how you are choosing the starting values for nls() in each case. Produce a figure depicting the estimated curves all on the same plot, along with the observed data. Be sure to include a legend to distinguish the different curves. • For each of the three models, give a 95% confidence interval for limt→∞f(t). What does this represent? • Select the best of the three models, and plot an estimate of the derivative df(t) dt , which represents the rate of growth over time.

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